产品货号：
Z15097
中文名称：
Cyclin D1/CCND1抗体
英文名称：
Anti-Cyclin D1/CCND1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Cyclin D1/CCND1 Antibody |
| 指标别名 | B cell lymphoma 1 protein;CCND1;cyclin D;Cyclin D1;D11S287E;G1/S specific cyclin D1;PRAD1;PRAD1 oncogene;U21B31 |
| 克隆性 | Polyclonal |
| 检验物种 | human,rat |
| 应用范围 | WB,FCM |
| 基因名称 | CCND1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Cyclin D1(19-37aa DANLLNDRVLRAMLKAEET),different from the related mouse and rat sequences by two amino acids. |
| 实际分子量 | 34KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Cyclin D1,also known as CCND1,is a human gene.The protein encoded by this gene belongs to the highly conserved cyclin family,whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle.Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma,breast cancer,colon cancer,lymphoma,melanoma,and prostate cancer.The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis.Brisken et al.(2003) found that prolactin (PRL;176760) induced IGF2 (147470) mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures.And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin,IGF2,and cyclin D1 are components of a developmental pathway in mammary gland. |
| Uniprot ID | P24385 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | cyclin D1 |
| 蛋白名全称 | G1/S-specific cyclin-D1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Flow cytometry (FCM) 1～3μg/1×106 cells |
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